Pedro San Segundo: "La levadura de gemación como modelo para descifrar los controles de calidad meióticos preventivos de trastornos reproductores"

24/01/2020

Meiosis is the specialized cell division that produces haploid gametes from diploid parental cells (gametogenesis). After fertilization, the normal chromosome complement is restored; therefore, the accuracy in the distribution of chromosomes to the gametes is critical for a healthy offspring and species survival. Meiotic errors result in aneuploidy and, in humans, they are the main cause of reproductive disorders, including infertility, spontaneous abortions or genetic birth defects, such as, for example, Down’s syndrome.During meioisis, a complex series of events (pairing, synapsis and recombination) leads to the establishment of physical connections between homologous chromosomes that orchestrate their segregation during the first meiotic division. Meiotic cells have developed surveillance mechanisms (checkpoints) that monitor proper distribution of genetic material to the progeny. This meiotic checkpoint network blocks cell cycle progression in response to defects in recombination and/or chromosome synapsis, thus preventing aberrant chromosome segregation and the formation of aneuploid gametes. Importantly, the incidence of aneuploidy in humans is higher than in other organisms displaying a significant increase with maternal age. Although several factors are involved, a weaker checkpoint response to face meiotic errors is one of the causes contributing to this high frequency of human aneuploidy. Therefore, investigating the molecular mechanisms underlying the control of meiotic chromosome dynamics by checkpoints is fundamental to unveil the causes of pregnancy losses, infertilityand genetic birth diseases.Las levaduras: en la intersección entre la Biología de sistemas y la BiomedicinaEnmemoriadelProfesorJulioRodríguez VillanuevaYeasts: at the cross-roads of Systems biology and BiomedicineIn memory of Professor Julio Rodríguez VillanuevaMadrid, 23 y 24 de enero de 2020 / January, 23 and 24, 2020 Historically, the budding yeast Saccharomyces cerevisiaehas been widely used in meiotic studies providing a myriad of crucial contributions to our current meiosis knowledge. In particular, S. cerevisiaepossesses robust meiotic quality control systems. The evolutionary conservation of checkpoint pathways, as well as the ample array of research tools available, enables budding yeast as a powerful system to understand the molecular basis of fertility problems. We will presentour advances in understanding the checkpoint mechanisms employed by yeast meiotic cells to respond to recombination and chromosome synapsis defects.

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Ciencias de la vida y de la materia las-levaduras-en-la-interseccion-entre-la-biologia-de-sistemas-y-la-biomedicina-en-memoria-del-profesor-julio-rodriguez-villanueva

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Pedro San Segundo: "La levadura de gemación como modelo para descifrar los controles de calidad meióticos preventivos de trastornos reproductores"

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